We investigate a method of extracting and fitting synthetic environmental covariates and pedigree information in multilocation trial data analysis to predict genotype performances in untested locations. Plant breeding trials are usually conducted across multiple testing locations to predict genotype performances in the targeted population of environments. The predictive accuracy can be increased by the use of adequate statistical models. We compared linear mixed models with and without synthetic covariates (SCs) and pedigree information under the identity, the diagonal and the factor-analytic variance-covariance structures of the genotype-by-location interactions. A comparison was made to evaluate the accuracy of different models in predicting genotype performances in untested locations using the mean squared error of predicted differences (MSEPD) and the Spearman rank correlation between predicted and adjusted means. A multi-environmental trial (MET) dataset evaluated for yield performance in the dry lowland sorghum (Sorghum bicolor (L.) Moench) breeding program of Ethiopia was used. For validating our models, we followed a leave-one-location-out cross-validation strategy. A total of 65 environmental covariates (ECs) obtained from the sorghum test locations were considered. The SCs were extracted from the ECs using multivariate partial least squares analysis and subsequently fitted in the linear mixed model. Then, the model was extended accounting for pedigree information. According to the MSEPD, models accounting for SC improve predictive accuracy of genotype performances in the three of the variance-covariance structures compared to others without SC. The rank correlation was also higher for the model with the SC. When the SC was fitted, the rank correlation was 0.58 for the factor analytic, 0.51 for the diagonal and 0.46 for the identity variance-covariance structures. Our approach indicates improvement in predictive accuracy with SC in the context of genotype-by-location interactions of a sorghum breeding in Ethiopia.